Gattaca Venit

Posted on October 20, 2018 by Professor Taboo

The title means “Gattaca Arrived.” In this scene of the 1997 SyFi film Gattaca, Vincent Freeman’s parents are planning a second child, as their first (Vincent) was unfortunately conceived “naturally” and “passionately.” The geneticist-consultant shows them four candidate embryos:

Geneticist: You have specified hazel eyes, dark hair and fair skin. I’ve taken the liberty of eradicating any potentially prejudicial conditions. Premature baldness, myopia… alcoholism and addictive susceptibility… propensity for violence, obesity, etc.

Marie Freeman: We didn’t want… Diseases, yes, but– [looks at Antonio]

Antonio Freeman: We were just wondering if it’s good to leave a few things to chance?

Geneticist: We want to give your child the best possible start. Believe me, we have enough imperfection built-in already. Your child doesn’t need any more additional burdens. Keep in mind, this child is still you. Simply the best of you. You could conceive naturally a thousand times and never get such a result.

Less than two decades after the film’s release it is no longer cinematic fiction. Editing our human DNA safely and wisely is here and will soon be available to the public. What this means is beyond profound and will change life as we know it forever! Please watch this 16-min TED video presentation from one of the co-founders of the CRISPR-CAS9 gene-editor, Dr. Jennifer Doudna.

Some of the questions Dr. Doudna raises and those presented to her at the end of her presentation were very good, very paramount questions for her, the scientific-medical community, and people in general, legislatures in particular, to seriously consider. This has created two nascent scientific-philosophical fields: bioethics and genethics.

The therapeutic uses for this medical technology are unquestionable when it comes to relief of human suffering and early mortality from diseases. One of its uses I personally find fascinating and optimistic about is that of combating addiction, heretical or acquired. The U.S.’s addiction-crisis of the brain’s reward-dopamine abuse is absolutely a treatable illness and disorder! This neurogenetic editing-rehab would have a major impact on our species and societies. For a poignant assessment of this current mental health epidemic and its solutions, click here. At the other end of the addiction spectrum there is one form of treatment which has proven a failure: abstinence. In fact, abstinence has shown for the last 70+ years to exacerbate recovery for almost all addicts.

But rewiring and editing neurological and genetic strands does raise some sub-questions. For example, when is giving charity or open-love or generosity an addiction (clinical co-dependency), and when is it healthy and not an addiction? For hundreds and thousands of years of human history, nowhere, no one group, organization, belief-system, or society has ever had a workable and successful answer — until modern medicine and science.

Then there are some non-therapeutic questions too. For example, here are some I picked out from the National Human Genome Research Institute’s website posted August 2017:

Regarding Properly Informed Consent

How can an informed choice/decision be offered to an unborn embryo of the edit(s) or to its descendants?
What exactly should define Properly Informed Consent?

Regarding Justice and Equity

How can the impoverished and disadvantaged (the world’s 80% – 90% population) people be assured that genome editing is available for all, not just the wealthy causing disparities throughout healthcare?
How will our species avoid germline editing that creates classes of individuals defined by the quality of their (purchased?) engineered genomes?

However these issues and questions play out, like it or not, gene-editing is here to stay. Whether the U.S. and other democratic nations are at the forefront of this Venit/Arrived technology, other questionable groups, societies, and nations, depending on their “resources,” will get a hold of it eventually, or do everything within their power to stop it or corrupt it. Which brings me to another profound question.

Don’t we have a moral, humane imperative and responsibility to ease and/or stop all suffering?

For me, the answer is Of course we do! It’s a no-brainer. But I am also very happy to report that this positive course of action implies another wonderful reality!

Since a supposed “God” fucked all this up in the first place — or allowed Satan to do so, whichever — in that light we can start doing the work that the mentally retarded, lazy, “God” with no foresight whatsoever has refused to do for well over 300,000 to 500,000 years! Let’s at least keep moving forward helping our reality in practical beneficial ways!

If you’d like to know more remarkable news about gene-editing, watch this 12-min TED video “Gene-editing Can Now Change An Entire Species.”

The positive benefits of utilizing gene-drives and DNA-repairing editors are endless and must be increasingly understood and discussed. At minimum, THAT is indeed what we are responsible for doing. Staying with status quo or what I’ve often described to the religious as stagnate-in-antiquation is a sure-fire way to accelerate extinction.

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Live Well — Love Much — Laugh Often — Learn Always

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If It Tastes Good

Posted on August 9, 2018 by Professor Taboo

Oh to be young again.

Has anyone found the Fountain of Youth? Because I’m running out of time here! And don’t give me that long-ass sales line about working out and eating a consistent healthy diet. I did that for 45-years being a very active young boy. Several athletic activities such as swimming, volleyball, baseball, and ultimately soccer/futebol that I pursued from secondary school, collegiate, and pro to semi-pro before retiring. During all of those years was that “strict healthy diet,” with occasionally ~~light~~ normal alcohol consumptions. It all worked rather well — complete physicals always ended with the doctor stating, “An excellent bill of health for your age sir.“

Then came the big 5 – 0.

∼ ∼ ∼ § ∼ ∼ ∼

Injuries sustained over a lifetime soccer career — both knees, one shoulder, one ankle, and 2-3 concussions… that I can remember — began limiting my physical activities, or at least the particular sports I enjoyed playing. Time to adapt.

I quickly discovered, however, that it really, really helps if you HAVE the time TO adapt! And as I also soon learned at that point, it all comes down to shuffling around, tossing out, plugging in various “priorities” within a 24-hour day. No more, no less. Twenty. Four. This is a workout in itself!

By the time I perfect this time-management, advanced calculus equation, I am 55-years old. My hair, what’s remaining on my crown and has moved en masse to my ears, nose, and neck, has turned essentially all silver-white. My daughter says I am now ready to be accepted into a band of gorillas as a silver-back — not to be confused with THE silver-back, she clarifies. Apparently in the years it took me to become a near replica of Sean Connery, in 30-seconds my daughter became a Primatologist with an acute sense of reality-checks. I will spare everyone the long list of “medical checks” and prevention measures men over 40 should (sometimes must) be alert to and inevitably embrace. Several methods are quite humbling and challenge even the most sturdiest of dignities.

Then with a vengeance came varicella-zoster. But at the time I had no idea why I felt like my left side head, neck, left tonsil, and left inner-ear were about to explode. My friend tells me I kept mumbling over and over “It hurts, it burns, I see Kate Beckinsale with Jessica Biel.“ This was rumour of course, and after all I was running a 103° temperature. An aging man cannot be held responsible for an unhinged subconscious!

After 3-days of total hell consciously and subconsciously, I had had enough. I was a defeated silver-back-n-top. Despite my long history of fainting at the sight of syringes, scalpels/lancets, needles, blood, and the occasional speech impediment around Nurse Goodbodee in librarian glasses, to the doctor I went. As I expected, this did not go as expected.

The nurse performed all the usual pre-diagnosis rituals, showed me my examination room and cushy table to place my buttocks to await the doctor. A few minutes pass, he enters, he corrects me 3-4 times about “Pugach,” pops the rubber gloves on, checks my head, stethoscope to the chest and back, then sits on his stool-with-rollers. “Your shingles“ the doctor from Belarus or Ukraine with an impossible last name to pronounce explained, “will go away in 4-6 weeks. But that’s not your biggest problem.“ I immediately start remembering the earlier pre-diagnosis checks: weight scale? Ear thermometer? Prostate check? Whew! Didn’t do that one. Pulse check? Blood-pressure monitor? The constant popping of 1500-2000 MGs of Extra Strength Tylenol for the Kate Beckinsale/Jessica Biel ailment? Are there severe side-effects for that? I just wasn’t sure what could be worse than my damn head and pain.

“Your blood-pressure is high; abnormally high.“ I was slightly relieved when he said that. I thought of many things much worse! “We’ll need to put you“ he continued “on some blood-pressure medications right away.“ I think cool, not a problem. “You’re closely approaching stroke-risk status.“ Great, let’s do it — the meds that is. “We’ll also need to do some lab work too… to check on enzyme levels and blood electrolytes, lipid profile, etc.“

Now we have a problem. “Well, if we don’t do lab work you’ll likely have bigger problems than the one in your head and on your head.“ He winked at me with a smirk. I thought, that’s not funny.

In the room ladened with every sort of life-threatening utensils and signs warning not to touch, discard here, and In Case of Emergency Do… I managed to get through the whole slapping the inside of the elbow, sterilization rub, needle enters, blood gushes out, fills the vile, undo the rubber strap off the arm, and then band-aid with a candy-lollipop. I walked out of that office a proud survivor and veteran of many floor deployments!

A day or two later the lab calls with my results. “Everything looks normal“ the kind lady informs me “but your liver enzymes are elevated.“ Okay, elevated is not all bad with a man’s body, right? “You need to cut-down on your carbohydrates, go on a low-carb diet, and probably cut way down on your alcohol consumption.“ I felt my body sink when she said the last part. Like… ALL alcohol, I asked her. “Wine, preferably reds, in moderation — say two or three glasses per week or one 8 oz glass per day — should be fine.“ However, she pretty much said no liquors in excess or heavy moderation. When I researched the low-carb diet, it wasn’t too bad, although several foods I’ve loved all my life — cheeses, breads, whole milk, coffee with gourmet creamers — had to go.

This felt as if I was loosing my closest dearest friends and even the ones that get you into untold troubles and complications of particular day-after regrets. Bye-bye. Gone. Send a postcard.

Then my follow-up doctor visit happened.

Same routines as previously with the marvelous exception of items designed to poke, puncture, probe, or cause general discomfort such as fainting and peeing (in a cup or in your pants) all remained out of eyesight and out of my body. I was thrilled! The soft knock-knock on the door and my doc with the impossible last name enters. All my problems and ailments are in decline — the fun news. We then begin discussing the low-carb diet and what it encompasses. He covers the “Okays to eat/drink” first, perhaps wanting to make me feel better… as most doctors are supposed to do. He names off a dozen or so and all of them I enjoy eating. It’s quite a tasty list of options. “Do you have our Low-Carb Diet pamphlet?“ No I replied. He walks over to the wall of pamphlets next to the big laminated poster entitled “Causes of Hypertension to the Human Body,” grabs my future meal plan and hands it to me.

There in green-ink I see the side of “Okay to eat/drink” list. Yep, check. Then on the other side of the page is the “Avoid – Do Not Eat/Drink.” In a most drabby voice I share my assessment of the diet, “Umm, the red Avoid side is noticeably longer.“ He acknowledges my keen observation; apparently he has heard this tone before. “Yes, a big reason for that are the enormous choices shoppers have at grocery stores and restaurants.“ Yeah, that’s true I say to myself, still mopey. I try to finagle some exceptions, or certain conservative amounts, frequencies, and volumes, but my doctor with the impossible last name is having none of it. He goes into a more extensive spill as to what exactly is best and what is iffy, wrong, and call the undertaker. I try one last attempt to skirt by, just on the edge, and he interrupts me. I guess he’s on a schedule?

“Basically, if it tastes good, spit it out!“

I look at him astonished with eyes bulging, mouth frozen. I’m unsure what to say. Then he begins chuckling, and explains he wanted to get me refocused on what is important. He then modified his hammering gavel to a softer “If it tastes sweet, spit it out.”

Well there, I felt much better. My doctor (and I suppose my body) put me on top of the geriatric world, only after one-hour… a bit older listening to my exhilarating new lifestyle! Strike up the marching band, but leave off the flutes, clarinets, saxophones, trumpets, trombones, the entire percussion section, and the tubas.

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Live Well — Love Much — Laugh Often — Learn Always — But Don’t Over Do It 😶

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Earth: She Gives, She Takes

Posted on July 26, 2018 by Professor Taboo

Just like as in a nest of boxes round,
Degrees of sizes in each box are found:
So, in this world, may many others be
Thinner and less, and less still by degree:
Although they are not subject to our sense,
A world may be no bigger than two-pence.
Nature is curious, and such works may shape,
Which our dull senses easily escape:
For creatures, small as atoms, may there be,
If every one a creature’s figure bear.
If atoms four, a world can make, then see
What several worlds might in an ear-ring be:
For, millions of those atoms may be in
The head of one small, little, single pin.
And if thus small, then ladies may well wear
A world of worlds, as pendents in each ear.

—— Margaret Cavendish, “Of Many Worlds in This World“

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Music: “Ocean” by Azam Ali & Loga Ramin Torkian from the album, Lamentation of Swans: A Journey Towards Silence

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Live Well — Love Much — Laugh Often — Learn Always

Masculinity

Posted on July 19, 2018 by Professor Taboo

THIS DESERVES PASSING ON! #EVOLVETHEDEFINITION

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There’s a difference between wisdom and arrogance. There’s a difference between persuading and Machiavellian. There’s a difference between astute and reckless. There’s a big difference between a baboon and being human. Let’s not lose these distinctions gentlemen. “Refined and civilized” has a much brighter future than brutish and uncouth. Is this really so hard to understand? Men, must we step-up (again) to teach and defend human decency?

The men’s fashion company, Bonobos takes one of the earliest steps in this 1:30 promo for a gender-responsible organization to reverberate a more accepting, broader, and diverse representation of what it means to evolve masculinity. What are your thoughts ladies and gentlemen?

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Live Well — Love Much — Laugh Often — Learn Always

Does Size Matter?

Posted on July 5, 2018 by Professor Taboo

My intelligence officer frantically bursts through my plastic door, salutes with the wrong hand and reports to me in broken sentences and insufficient oxygen-intake THE terrible crisis which has befallen us:

Highly General! We’ve been hit by a surprise attack that is of the scale and deadly precision of… yes… Dec. 7th, 1941… “A date which will live in INFAMY!“

Stunned and not sure whether I left the refrigerator door open this morning or not, and whether I remembered to apply my under-arm deodorant, I asked my IO “Alright, so how bad is it? What’s the damage report?”

Sir of Highlyness, the reports are still preliminary, but all sectors are fighting gallantly in all directions! But there is just TOO MANY of them. We are being overrun!

I scramble to find somewhere on my big desk in front of my BIG chair underneath all my “kinky surveillance photos” and questionable magazines, “Where is that file? I know it’s here somewhere!” Shuffle, shuffle, push, push… “HAH! There it is!” My IO with the utmost attentiveness of a feline inside a pet-bird store snaps “WHAT!? What is it your Highlyness!?”

I open up the top-secret file labelled “Top Secret” to read valuable national security data for kitchens:

If you have been seeing small flies or gnats in your kitchen, they’re probably fruit flies. Fruit flies can be a problem year round, but are especially common during late summer/fall because they are attracted to ripened or fermenting fruits and vegetables.

There it is. The Coup d’état of preemptive covert preparations in early to mid-April. Yes, APRIL! What good does that do us in June under piles of kinky photos and unconventional magazine… research!? The extensive report continues:

Adults are about 1/8 inch long and usually have red eyes. The front portion of the body is tan and the rear portion is black. Fruit flies lay their eggs near the surface of fermenting foods or other moist, organic materials. Upon emerging, the tiny larvae continue to feed near the surface of the fermenting mass. This surface-feeding characteristic of the larvae is significant in that damaged or over-ripened portions of fruits and vegetables can be cut away without having to discard the remainder for fear of retaining any developing larvae. The reproductive potential of fruit flies is enormous; given the opportunity, they will lay about 500 eggs. The entire life-cycle from egg to adult can be completed in about a week.

Obviously I cannot confirm the red eyes because the little f*ckers never stay still, especially when I try to look up close directly at their eyes! Tan bodies? What!? Are they migrating here from Caribbean beaches of UV-coconut lotion? Wow, what a life!

Eggs on fermenting foods or organic materials? That is unequivocally wrong! I have nothing fermenting within my zone-of-defense and most grocers don’t sell anything organic, at least not at reasonable prices! Damn, these little pecker-pests have figured out another method of infiltration and penetration! And I am NOT talking about Karen McDougal or Stormy Daniels. HOLY SHIT! 500 eggs!? “The entire life-cycle from egg to adult can be completed in about [30-seconds].” Well, at least that’s much much longer than Donnie T’s endurance.

As I am reading this Top Secret file I have three enemy flies/gnats buzz me. One tries entry into my nostril the other tries my ear like my skull is the Death Star and they have delusions of Luke Skywalker grandeur! “OH HELL NO!” I’m swatting my hands everywhere like M.C. Hammer on steroids firing laser-machine-guns! BAAM! BOOM! gnatty-ness carnage everywhere!

But within minutes there’s another wave of horny-for-500-more fruity flies flying to my kitchen and to every orifice on my body… I presume because I do not have enough organic produce! Hence, I am the fruiter’s target. I must read the rest of the Top Secret fruit-fly files FAST… EEER!

ERADICATION – or Counter-attacks:
Once a structure is infested with fruit flies, all potential breeding areas must be located and eliminated. Unless the breeding sites are removed or cleaned, the problem will continue no matter how often insecticides are applied to control the adults. Finding the source(s) of attraction and breeding can be very challenging and often will require much thought and persistence. Potential breeding sites which are inaccessible (e.g., garbage disposals and drains) can be inspected by taping a clear plastic food storage bag over the opening overnight. If flies are breeding in these areas, the adults will emerge and be caught in the bag.

Are you fuckin’ kidding me? I have to find areas with 500 eggs? And we thought Easter was fun!?

I scream at my IO, “Corporal Klinger! It is time to call-in SEAL Team D-O. We have no choice, no hope of clean orifices if we do not call-in the Specialized DO-ers.”

Cpl. Klinger, Intelligence Officer

Cpl. Klinger stares forward and stares forward… “KLINGER!” He jumps to attention, “SIR!?” I give him the piercing reprimand-stare, “This is no time for daydream believers and homecoming Queens! Make the call!” He salutes proudly, “Yes sir. Right away sir! I’m sure the Black-Ops of Drain-O squad will see to it that Operation Orifice is a resounding success!”

“Well, it better be or we will become the 30-second breeding ground of eggs-galore! Can you imagine being violated like that in 30-seconds?” Both of us pause a few seconds and remember the long, long history of patriarchal plunder. Cpl. Klinger begins to open his mouth to respond. “STOP! Do not answer that.”

“Right now we have a formidable fruit-fly foray requiring our finest feats of ferocity! Are you fit for this forthcoming fatal function of fracas fruit-fly…” I must pause to wipe my lip and chin… “FARNAGE!“ the Cpl. blurts out! “You are indeed my fashionable Intelligence Officer. Go call SEAL team DO-ers!”

The Battle-Smoke Slowly Clears, the Smell of Apple Vinegar Lingers with Fly-Bodies Floating Lifeless Everywhere

💀 💀 💀 💀 💀

It was near disaster. There were so many. They just kept coming and coming and coming. Three bottles of apple-cider vinegar (squirted with Dawn dishsoap) gone, strategically dispersed throughout our fortress defenses, precision counter-attacks by the SEAL DO-ers, and orifices brilliantly booby-trapped… the war had been won, but at what cost? Would we be able to withstand the next attack? Unless we breed like our fruity enemy do we have a chance? Yes, we were victors, for now. Like the dinosaurs we are big and mighty, for now. But can we last?

Do numbers matter? Scary still, does size matter? We face an uncertain future with those levels of reproduction and libidos. I don’t think we hetero males will keep up. Have we been deluding ourselves over the millenia with dreams of superiority?

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Live Well — Make Love Much More? — Laugh Often at our Arrogance — Learn Always from the Tiny Details